Biocompatible Glue and Glue Gun for Wound Closure

25 June 2019

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Researchers at the Technion-Israel Institute of Technology in Haifa have developed a non-toxic biocompatible glue and glue gun capable of closing wounds quickly without causing any toxic side effects.

The glue has been designed as an alternative to pins, stitches and staples that can be painful, cause permanent scarring, and often need to be removed once the would has healed. With the scrutiny that surgical staplers are currently undergoing regarding their safety, it is hoped the glue will be a safer alternative for the closure of incisions and wounds.

Medical glues have commonly been used in the dermatology and cosmetic surgery fields, however, they are limited by their toxicity; because of this, they can only be used on superficial wounds or on the skin's surface. Current glues and are also less flexible and can become weaker once they’ve hardened.

The biocompatible glue is comprised of a four‐armed N‐hydroxy succinimide‐modified polycaprolactone, which has a low melting point and was formulated by altering its molecular weight. This allows its adhesive strength, melting point and elasticity to modified as necessary. The glue then naturally decomposes within a few weeks and then can easily be peeled off.

“The internal temperature of a ‘regular’ glue gun is about 160 degrees Celsius. To avoid tissue damage and pain, we have designed a special glue gun having an internal temperature of 50 degrees Celsius,” said Technion Biomaterials Laboratory head Prof. Boaz Mizrahi

Although clinical studies have not yet begun, lab and animal studies have so far confirmed the glue and its accompany glue gun to be safe and effective.